Calculation
PER = price / EPS. Trailing uses past profit; the forward, estimates. It is also equivalent to capitalization / attributable profit if dates and actions are consistent. A negative profit makes the ratio insignificant.
What it contains
A high P/E may reflect growth, duration, stability or low rates; a low one can signal cyclicality, debt or deterioration. The multiple compresses many assumptions, which is why they must be broken down.
Example
Company A at 30x grows EPS 20% and reinvests well; B at 10x is in a cyclical peak and its profit may fall 50%. B is not necessarily cheaper.
Valid comparisons
Compare with your own history adjusted to the cycle and with similar models. Ensures same definition of EPS and debt. Banks, software and manufacturers do not deserve the same framework.
From ratio to decision
Projects normalized EPS and a range of multiples consistent with growth and risk. Calculate return including dividends and possible contraction. Contrast with FCF to detect profit without cash.